* Adapted from Sunnybrook Hospital
Trimethoprim (TMP) | Sulfamethoxazole (SMX) | |
---|---|---|
Suspension | 8 mg/ml | 40 mg/ml |
Injectable | 16 mg/ml | 80 mg/ml |
SS (single strength) tablet | 80 mg | 400 mg |
DS (double strength) tablet | 160 mg | 800 mg |
* 2 SS tabs = 1 DS tab= 20 mL oral suspension = 10mL IV
Trimethoprim/sulfamethoxazole is dosed by trimethoprim (TMP) component.
Common doses of oral TMP/SMX:
Regimen | Total mg of TMP / day |
---|---|
1 SS BID | 160 mg |
1 DS BID | 320 mg |
1 DS TID | 480 mg |
1 DS QID | 640 mg |
2 DS BID | 640 mg |
2 DS TID | 960 mg |
2 DS QID | 1280 mg |
3 DS TID | 1440 mg |
If Intravenous Cotrimoxazole is Required
10 mg/kg TMP per Day
Weight (kg) | IV Dose | Total TMP Dose (mg/day) |
---|---|---|
40-49 | 10 mL Q8H | 480 |
50-64 | 10 mL Q6H | 640 |
65-74 | 15 mL Q8H | 720 |
75-99 | 15 mL Q6H | 960 |
100-129 | 20 mL Q6H | 1280 |
15 mg/kg TMP per Day
Weight (kg) | IV Dose | Total TMP Dose (mg/day) |
---|---|---|
40-44 | 10 mL Q6H | 640 |
45-49 | 15 mL Q8H | 720 |
50-69 | 15 mL Q6H | 960 |
70-79 | 25 mL Q8H | 1200 |
80-89 | 20 mL Q6H | 1280 |
90-99 | 30 mL Q8H | 1440 |
100-109 | 25 mL Q6H | 1600 |
110-119 | 35 mL Q8H | 1680 |
120-129 | 30 mL Q6H | 1920 |
20 mg/kg TMP per Day
Weight (kg) | IV Dose | Total TMP Dose (mg/day) |
---|---|---|
40-54 | 15 mL Q6H | 960 |
55-69 | 20 mL Q6H | 1280 |
70-79 | 30 mL Q8H | 1440 |
80-89 | 25 mL Q6H | 1600 |
90-104 | 30 mL Q6H | 1920 |
105-119 | 35 mL Q6H | 2240 |
120-134 | 40 mL Q6H | 2560 |
Creatinine Clearance | Suggested Dosing Guidelines |
---|---|
> 30mL/min | Bacterial infections: 8-12mg/kg/day of TMP in 2 – 4 divided doses PJP: 15-20mg/kg/day of TMP in 2 – 4 divided doses |
10 – 30 mL/min | Bacterial infections: 75% of usual dose (6 – 9 mg/kg/day of TMP in 2 – 4 divided doses) PJP: 12-15mg/kg/day of TMP in 2 – 4 divided doses |
< 10 mL/min (including PD) | Generally not recommended If required: use 50% of usual doses Bacterial infections: 5mg/kg/day in 2 – 4 divided doses PJP: 7.5-10mg/kg/day of TMP in 2-4 divided doses |
Hemodialysis | 50% of usual dose – schedule doses post-dialysis |
Continuous Renal Replacement Therapy (CRRT) | Bacterial infections: 7.5mg/kg/day of TMP in 2-4 divided doses PJP/ Stenotrophomonas: 15mg/kg/day of TMP in 2- 4 divided doses |